Table 3.
Differences, by UGT1A1*28 genotype, in time from diagnosis, metastatic disease and treatment
6/6 | 6/7 | 7/7 | ALL (n=329) | |
---|---|---|---|---|
n=137 | n=153 | n=39 | ||
Time (in weeks) from initial diagnosis and treatment start (p=0.014)& | ||||
Median | 62 | 39 | 42 | 48 |
Inter-quartile Range | 22–122 | 11–86 | 11–97 | 13–109 |
Time (in weeks) from 1st metastasis/recurrence to treatment start (p=0.13)& | ||||
Median | 13 | 11 | 13 | 12 |
Inter-quartile Range | 6–38 | 5–23 | 8–38 | 6–30 |
Treatment protocol^ (p=0.69) | ||||
FOLFIRI | 42% | 37% | 28% | 38% |
IFL | 37% | 44% | 44% | 41% |
Other irinotecan-based (TEGAFIRI, XELIRI) | 21% | 19% | 28% | 21% |
chi-Square test
Kruskal-Wallis test
In patients with genotype and full oncological follow-up