Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
PP6 is required for HDR of I-SceI-induced DSBs. (A) Simplified diagram of the HDR reporter system. (B) Depletion of PP6c results in a defective HDR of I-SceI-induced DSBs. PP2cA-, PP4C- or mock-depleted DRGFP U2OS cells were transfected with I-SceI. PP2cA- or PP4C-depleted cells were positive controls. Two days later, cells were collected and analyzed for GFP expression by FACS. All data are the average of three independent experiments, bars are SD. *p < 0.05.
