Fig. 3.

Initial five minutes of activity was isolated in order to re-assess sensitization to the locomotor stimulating effects of ethanol (as this was the only time period during which adults and adolescents both showed ethanol-induced hyperlocomotion following acute administration: see Fig. 3). a-b) There was no evidence of sensitization for B6 adolescents or adults. c-d) D2 adults showed increased activity when comparing Day 14 to Day 3 for all repeated doses (* ; p’s <0.0001), and adolescents for all doses (p’s<0.001) except 3.5g/kg. D2 adults showed a significant difference between repeated saline and repeated ethanol administration at all doses († ; p’s<0.001), whereas D2 adolescents only show a significance following the lowest dose of repeated ethanol administration (2.5g/kg; p<0.0001).