Table 4.

Unadjusted and adjusted odds ratios for the TT genotype of predicting the dichotomous outcomes of ‘likely substance dependence’ [based on Kreek–McHugh–Schluger–Kellogg (KMSK) cut scores] versus control subjects in African American women.

	Unadjusted [P value]	Adjusted for HIV serostatus [P value]	Adjusted for HIV, age, income and education [P value]
‘Likely opiate dependence’ versus controls	1.5 (0.4–5.1) [0.53]	1.6 (0.5–5.6) [0.46]	1.4 (0.3–6.1) [0.65]
‘Likely alcohol dependence’ versus controls	3.7 (1.6–8.4) [0.003]	3.6 (1.5–8.3) [0.003]	3.0 (1.1–8.0) [0.03]
‘Likely coeaine dependence’ versus controls	2.8 (1.8–6.4) [0.014]	2.7 (1.2–6.2) [0.02]	2.0 (0.8–5.2) [0.14]

The numbers in each cell are odds ratios, 95% confidence intervals and significance levels. The TT genotype was found in 8 out of 230 controls, 24 of 261 with ‘likely cocaine dependence’, 20 of 173 with ‘likely alcohol dependence’ and 4 of 79 with ‘likely opiate dependence’ (because controls exclude subjects with some substance use, the number of subjects with the TT genotype do not sum up to 42—the total number of African American participants with the TT genotype).