Table 2.
PI and MFV of Insonated Arteries in NDC, MCI and AD Subjects
| Insonated Artery |
Sample Size (n) |
NDC Mean (SD) |
MCI Mean (SD) |
AD Mean (SD) |
p1 |
|---|---|---|---|---|---|
| Pulsatility Index | |||||
|
| |||||
| LdMCA | 87 | 1.11 (0.24) | 1.18 (0.24) | 1.28 (0.34) | .0612 |
| LpMCA | 96 | 1.11 (0.22) | 1.19 (0.28) | 1.25 (0.25) | .0362 |
| LACA | 90 | 1.05 (0.36) | 1.17 (0.21) | 1.24 (0.34) | .0772 |
| LPCA | 85 | 1.00 (0.21) | 1.05 (0.18) | 1.18 (0.31) | .0252 |
| Lsiph | 101 | 1.13 (0.21) | 1.21 (0.28) | 1.44 (0.45) | .0022 |
| LICA | 101 | 1.20 (0.26) | 1.37 (0.21) | 1.29 (0.26) | .052 |
| LVA | 98 | 1.12 (0.20) | 1.11 (0.11) | 1.15 (0.24) | .766 |
| pBA | 99 | 1.04 (0.25) | 1.08 (0.20) | 1.20 (0.41) | .1132 |
| dBA | 97 | 1.00 (0.19) | 1.12 (0.22) | 1.16 (0.23) | .0072 |
| RdMCA | 95 | 1.06 (0.21) | 1.16 (0.28) | 1.23 (0.23) | .0062 |
| RpMCA | 99 | 1.04 (0.20) | 1.14 (0.22) | 1.22 (0.25) | .0052 |
| RACA | 97 | 1.10 (0.19) | 1.11 (0.24) | 1.17 (0.24) | .315 |
| RPCA | 90 | 1.05 (0.26) | 1.09 (0.22) | 1.21 (0.30) | .0582 |
| Rsiph | 100 | 1.20 (0.24) | 1.38 (0.27) | 1.39 (0.45) | .0202 |
| RICA | 102 | 1.21 (0.23) | 1.35 (0.23) | 1.37 (0.23) | .0082 |
| RVA | 97 | 1.11 (0.31) | 1.12 (0.23) | 1.24 (0.43) | .327 |
|
| |||||
| Mean Flow Velocity | |||||
|
| |||||
| LdMCA | 87 | 38.14 (11.62) | 37.22 (11.52) | 30.68 (10.87) | .0262 |
| LpMCA | 96 | 39.04 (11.66) | 38.82 (14.65) | 33.13 (10.19) | .056 |
| LACA | 90 | 39.91 (12.53) | 35.40 (11.15) | 34.00 (16.00) | .183 |
| LPCA | 85 | 30.95 (8.62) | 32.53 (17.25) | 24.91 (7.95) | .0172 |
| Lsiph | 101 | 31.69 (7.98) | 33.64 (8.15) | 26.41 (7.03) | .0032,3 |
| LICA | 101 | 32.79 (6.79) | 31.27 (6.60) | 26.64 (7.34) | .0012 |
| LVA | 98 | 27.04 (10.34) | 27.55 (7.12) | 23.08 (7.19) | .066 |
| pBA | 99 | 28.29 (7.69) | 28.18 (5.21) | 24.79 (8.41) | .123 |
| dBA | 97 | 31.73 (8.00) | 28.36 (3.93) | 27.00 (8.60) | .0302 |
| RdMCA | 94 | 39.55 (12.62) | 31.80 (8.23) | 28.35 (10.09) | .0012 |
| RpMCA | 99 | 40.85 (10.87) | 41.09 (13.84) | 32.83 (10.93) | .0062 |
| RACA | 98 | 37.23 (11.63) | 33.92 (11.07) | 32.64 (12.33) | .218 |
| RPCA | 90 | 32.24 (11.55) | 28.90 (7.13) | 27.86 (12.62) | .252 |
| Rsiph | 100 | 32.21 (8.64) | 30.55 (7.71) | 27.66 (9.34) | .0802 |
| RICA | 102 | 32.12 (7.36) | 30.64 (6.45) | 27.33 (8.17) | .0252 |
| RVA | 97 | 25.79 (8.06) | 26.64 (4.54) | 22.95 (7.64) | .118 |
p-value for Welch’s-weighted ANOVA
p<.05 for Tukey-Kramer adjustment for comparison of means between non-demented controls and Alzheimer’s disease subjects
p<.05 for Tukey-Kramer adjustment for comparison of means between mild cognitive impairment and Alzheimer’s disease subjects
Abbreviations: NDC, non-demented control; MCI, mild cognitive impairment; AD, Alzheimer’s disease; dBA, distal basilar artery; LACA, left anterior cerebral artery; LdMCA, left distal middle cerebral artery; LICA, left internal carotid artery; LpMCA, left proximal middle cerebral artery; LPCA, left posterior cerebral artery; Lsiph, left siphon; LVA, left vertebral artery; pBA, proximal basilar artery; RACA, right anterior cerebral artery; RICA, right internal carotid artery; RdMCA, right distal middle cerebral artery; RPCA, right posterior cerebral artery; RpMCA, right proximal middle cerebral artery; Rsiph, right siphon; RVA, right vertebral artery