Table 2.
Controls (N=26,677) |
Ductal breast cancer (N=18,329) |
Lobular breast cancer (N=2,030) |
P-value ductal vs. lobular |
Mixed ductal-lobular breast cancer (N=907) |
P-value Mixed vs. lobular |
|||||
---|---|---|---|---|---|---|---|---|---|---|
Age at first birth | N | N | OR (95% CI) | N | OR (95% CI) | N | OR (95% CI) | |||
Nulliparous | 3,172 | 2,548 | 1.19 (1.08–1.31) | 247 | 1.72 (1.34–2.20) | 0.004 | 111 | 1.09 (0.77–1.54) | 0.03 | |
<20 | 4,323 | 2,516 | 1 | 234 | 1.00 | 121 | 1 | |||
20–24 | 11,476 | 7,298 | 1.07 (1.01–1.13) | 790 | 1.25 (1.07–1.46) | 0.05 | 330 | 0.99 (0.79–1.23) | 0.08 | |
25–29 | 5,534 | 4,118 | 1.22 (1.14–1.31) | 796 | 1.71 (1.44–2.04) | <0.001 | 232 | 1.36 (1.06–1.73) | 0.12 | |
30+ | 2,172 | 1,849 | 1.31(1.20–1.43) | 263 | 2.38 (1.94–2.93) | <0.001 | 113 | 1.55 (1.15–2.07) | 0.01 | |
P-trend (per 1 year)c | <0.001 | <0.001 | <0.001 | |||||||
5-Year increment | 1.11 (1.08–1.14) | 1.32 (1.24–1.40) | 1.23 (1.12–1.34) |
Includes ductal, lobular, and mixed ductal-lobular only (other histologic subtypes were excluded from analysis (N=1577)). Odds ratios are adjusted for age, state of residence, study period, parity, age of menarche, menopausal status, age at menopause, postmenopausal hormone use, oral contraceptive use, family history of breast cancer, recent alcohol consumption, body mass index, history of mammographic screening, and education.
P-trend calculated among parous women only.