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. Author manuscript; available in PMC: 2012 Jul 1.
Published in final edited form as: Arterioscler Thromb Vasc Biol. 2011 Apr 21;31(7):1547–1554. doi: 10.1161/ATVBAHA.111.226456

Figure 3.

Figure 3

Role of NOS uncoupling on endothelial dysfunction induced by partial carotid ligation. ApoE−/− mice underwent partial carotid ligation and were fed a high fat diet for 1 week. The animals were randomized to receive oral BH4 or vehicle following carotid ligation. Arterial rings were obtained from LCA and RCA of these mice for vascular ring activity measurements. A. Rings were pre-constricted with phenylephrine and responses evoked by increasing concentrations of acetylcholine for endothelium-dependent relaxation (n=6–8). B. Responses to increasing concentrations of sodium nitroprusside (SNP) were studied to assess endothelium-independent relaxation (n=6–8). Values were compared using repeated measures ANOVA and selected comparisons were made using a Bonferroni post hoc test.