Table 2.
Clinicopathologic characteristics according to groups by K means clustering analysis
| Group 1:low methyl | 2: intermediate | 3:high methyl | p value | |
|---|---|---|---|---|
| No | 99 | 40 | 22 | |
| Age | ||||
| mean | 60.8 | 59.3 | 64.3 | 0.257 |
| Sex | ||||
| Male | 60 | 22 | 11 | 0.608 |
| Female | 39 | 18 | 11 | |
| Site | ||||
| Proximal | 42 | 16 | 18 | 0.002* |
| Distal | 57 | 24 | 4 | |
| Histology | ||||
| Adeno | 94 | 38 | 21 | 0.995 |
| Mucinous | 5 | 2 | 1 | |
| Differentiation | ||||
| WD | 12 | 5 | 1 | 0.646 |
| MD | 78 | 32 | 18 | |
| PD | 4 | 1 | 2 | |
| T stage | ||||
| 1 | 3 | 0 | 0 | 0.344 |
| 2 | 8 | 5 | 2 | |
| 3 | 74 | 26 | 13 | |
| 4 | 14 | 9 | 7 | |
| N stage | ||||
| 1 | 70 | 26 | 15 | 0.802 |
| 2 | 29 | 14 | 7 | |
| Recurrence | ||||
| No | 67 | 29 | 12 | 0.424 |
| Yes | 28 | 11 | 9 | |
| LINE1 | ||||
| mean±SD | 50.1±8.4 | 50.4±4.6 | 53.6±6.2 | 0.14 |
| MSI status** | ||||
| MSS or MSI-L | 47 | 21 | 6 | 0.034* |
| MSI-H | 10 | 2 | 5 | |
WD, well differentiated; MD, moderately differentiated; PD, Poorly differentiated; Adeno, adenocarcinoma: Mucinous, mucinous adenocarcinoma
*
significant difference among groups by K means clustering analysis
**
available for a subset of patients only