Figure 6.

The ketone-induced gene signature is associated with ER(+) breast cancer and predicts poor clinical outcome. (A) Boxplots illustrate differential regulation of the ketone signature expression in breast cancer versus healthy breast tissue. Arrows indicate the directionality of differential regulation within each population. (B) Survival curves within low and high ketone signature-expressing populations are shown for overall survival in ER-positive breast cancer. This signature contains ∼4,141 genes (See Sup. Table 2).