Table 1.
Cellular processes increased in MCF7 cells treated with lactate
| Data Set | P value | Detailed Description |
| Stem Cells | ||
| STEMCELL_NEURAL_UP | 8.45E-23 | Enriched in mouse neural stem cells, compared to differentiated brain and bone marrow cells |
| STEMCELL_EMBRYONIC_UP | 9.31E-17 | Enriched in mouse embryonic stem cells, compared to differentiated brain and bone marrow cells |
| STEMCELL_HEMATOPOIETIC_UP | 1.11E-07 | Enriched in mouse hematopoietic stem cells, compared to differentiated brain and bone marrow cells |
| STEMCELL_COMMON_UP | 9.95E-05 | Enriched in mouse embryonic, neural and hematopoietic stem cells, compared to differentiated brain and bone marrow cells |
| HSC_LTHSC_ADULT | 1.94E-04 | Upregulated in mouse long-term functional hematopoietic stem cells from adult bone marrow (LT-HSC Shared + Adult) |
| HSC_LTHSC_FETAL | 4.79E-04 | Upregulated in mouse long-term functional hematopoietic stem cells from fetal liver (LT-HSC Shared) |
| HSC_LTHSC_SHARED | 4.79E-04 | Upregulated in mouse long-term functional hematopoietic stem cells from both adult bone marrow and fetal liver (Cluster i, LT-HSC Shared) |
| HADDAD_HSC_CD10_UP | 1.46E-03 | Genes upregulated in human hematopoietic stem cells of the line CD45RA(hi) Lin− CD10+, which are biased toward developing into B cells, versus CD45RA(int) CD7− and CD45RA(hi) CD7+. |
| DNA Damage Response | ||
| UVC_XPCS_ALL_DN | 4.57E-23 | Downregulated at any timepoint following treatment of XPB/CS fibroblasts with 3 J/m2 UVC |
| UVC_XPCS_8HR_DN | 7.07E-21 | Downregulated at 8 hours following treatment of XPB/CS fibroblasts with 3 J/m2 UVC |
| UVC_TTD_ALL_DN | 9.84E-18 | Downregulated at any timepoint following treatment of XPB/TTD fibroblasts with 3 J/m2 UVC |
| UVC_TTD_4HR_DN | 5.80E-15 | Downregulated at 4 hours following treatment of XPB/TTD fibroblasts with 3 J/m2 UVC |
| UVC_XPCS_4HR_DN | 8.87E-11 | Downregulated at 4 hours following treatment of XPB/CS fibroblasts with 3 J/m2 UVC |
| UVC_TTD-XPCS_COMMON_DN | 2.23E-09 | Downregulated at any timepoint following treatment of both XPB/CS and XPB/TTD fibroblasts with 3 J/m2 UVC |
| UVB_NHEK1_DN | 2.47E-09 | Downregulated by UV-B light in normal human epidermal keratinocytes |
| UVC_TTD_8HR_DN | 1.33E-08 | Downregulated at 8 hours following treatment of XPB/TTD fibroblasts with 3 J/m2 UVC |
| Breast Cancer | ||
| BRCA_ER_NEG | 8.50E-06 | Genes whose expression is consistently negatively correlated with estrogen receptor status in breast cancer—higher expression is associated with ER-negative tumors |
| Transcription Factors and Signaling Molecules Associated with Proliferation, Stemness and Cell Migration | ||
| GGGCGGR_V$SP1_Q6 | 8.22E-11 | Genes with promoter regions [−2 kb, 2 kb] around transcription start site containing the motif GGGCGGR which matches annotation for SP1: Sp1 transcription factor |
| GGGAGGRR_V$MAZ_Q6 | 2.68E-08 | Genes with promoter regions [−2 kb, 2 kb] around transcription start site containing the motif GGGAGGRR which matches annotation for MAZ: MYC-associated zinc finger protein (purine-binding transcription factor) |
| TTGTTT_V$FOXO4_01 | 3.17E-08 | Genes with promoter regions [−2 kb, 2 kb] around transcription start site containing the motif TTGTTT which matches annotation for MLLT7: myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 7 |
| CTTTGT_V$LEF1_Q2 | 7.86E-08 | Genes with promoter regions [−2 kb, 2 kb] around transcription start site containing the motif CTTTGT which matches annotation for LEF1: lymphoid enhancer-binding factor 1 |
| CAGGTG_V$E12_Q6 | 6.84E-07 | Genes with promoter regions [−2 kb, 2 kb] around transcription start site containing the motif CAGGTG which matches annotation for TCF3: transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47) |
| SCGGAAGY_V$ELK1_02 | 7.88E-07 | Genes with promoter regions [−2 kb, 2 kb] around transcription start site containing the motif SCGGAAGY which matches annotation for ELK1: ELK1, member of ETS oncogene family |
| GCM_MAP4K4 139 | 2.60E-06 | Neighborhood of MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 in the GCM expression compendium |
| HSA04510_FOCAL_ADHESION | 1.55E-05 | Genes involved in focal adhesion |
| GCM_ERBB2IP 53 | 2.54E-05 | Neighborhood of ERBB2IP erbb2 interacting protein in the GCM expression compendium |
| BRENTANI_SIGNALING | 8.04E-04 | Cancer related genes involved in the cell signaling |