Table 2.
Cellular processes increased in MCF7 cells treated with ketones
| Data Set | P value | Detailed Description |
| Stem Cells | ||
| STEMCELL_HEMATOPOIETIC_UP | 2.88E-09 | Enriched in mouse hematopoietic stem cells, compared to differentiated brain and bone marrow cells |
| STEMCELL_EMBRYONIC_UP | 6.29E-04 | Enriched in mouse embryonic stem cells, compared to differentiated brain and bone marrow cells |
| STEMCELL_NEURAL_UP | 6.74E-04 | Enriched in mouse neural stem cells, compared to differentiated brain and bone marrow cells |
| DNA Damage Response | ||
| UVC_XPCS_ALL_DN | 2.75E-13 | Downregulated at any timepoint following treatment of XPB/CS fibroblasts with 3 J/m2 UVC |
| UVC_XPCS_8HR_DN | 1.39E-12 | Downregulated at 8 hours following treatment of XPB/CS fibroblasts with 3 J/m2 UVC |
| UVC_XPCS_4HR_DN | 5.34E-07 | Downregulated at 4 hours following treatment of XPB/CS fibroblasts with 3 J/m2 UVC |
| UVC_TTD_ALL_DN | 6.87E-07 | Downregulated at any timepoint following treatment of XPB/TTD fibroblasts with 3 J/m2 UVC |
| UVC_TTD_4HR_DN | 6.16E-06 | Downregulated at 4 hours following treatment of XPB/TTD fibroblasts with 3 J/m2 UVC |
| UVC_TTD_8HR_DN | 2.07E-05 | Downregulated at 8 hours following treatment of XPB/TTD fibroblasts with 3 J/m2 UVC |
| UVB_NHEK1_DN | 2.45E-05 | Downregulated by UV-B light in normal human epidermal keratinocytes |
| UVB_NHEK3_C8 | 8.75E-05 | Regulated by UV-B light in normal human epidermal keratinocytes, cluster 8 |
| UVC_LOW_ALL_DN | 9.29E-05 | Downregulated at any timepoint following treatment of WS1 human skin fibroblasts with UVC at a low dose (10 J/m2) (clusters c1–c5) |
| Breast Cancer | ||
| BRCA_ER_POS | 1.15E-04 | Genes whose expression is consistently positively correlated with estrogen receptor status in breast cancer—higher expression is associated with ER-positive tumors |
| Transcription Factors and Signaling Molecules Associated with Proliferation, Stemness and Migration | ||
| GGGCGGR_V$SP1_Q6 | 1.00E-13 | Genes with promoter regions [−2 kb, 2 kb] around transcription start site containing the motif GGGCGGR which matches annotation for SP1: Sp1 transcription factor |
| CAGGTG_V$E12_Q6 | 7.79E-11 | Genes with promoter regions [−2 kb, 2 kb] around transcription start site containing the motif CAGGTG which matches annotation for TCF3: transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47) |
| TTGTTT_V$FOXO4_01 | 2.37E-08 | Genes with promoter regions [−2 kb, 2 kb] around transcription start site containing the motif TTGTTT which matches annotation for MLLT7: myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 7 |
| HSA04510_FOCAL_ADHESION | 3.76E-07 | Genes involved in focal adhesion |
| TGACAGNY_V$MEIS1_01 | 2.21E-06 | Genes with promoter regions [−2 kb, 2 kb] around transcription start site containing the motif TGACAGNY which matches annotation for MEIS1: Meis1, myeloid ecotropic viral integration site 1 homolog (mouse) |
| GGGAGGRR_V$MAZ_Q6 | 3.65E-06 | Genes with promoter regions [−2 kb, 2 kb] around transcription start site containing the motif GGGAGGRR which matches annotation for MAZ: MYC-associated zinc finger protein (purine-binding transcription factor) |
| CTTTGT_V$LEF1_Q2 | 4.63E-06 | Genes with promoter regions [−2 kb, 2 kb] around transcription start site containing the motif CTTTGT which matches annotation for LEF1: lymphoid enhancer-binding factor 1 |
| TCANNTGAY_V$SREBP1_01 | 1.09E-05 | Genes with promoter regions [−2 kb, 2 kb] around transcription start site containing the motif TCANNTGAY which matches annotation for SREBF1: sterol regulatory element binding transcription factor 1 |
| GGGTGGRR_V$PAX4_03 | 1.38E-05 | Genes with promoter regions [−2 kb, 2 kb] around transcription start site containing the motif GGGTGGRR which matches annotation for PAX4: paired box gene 4 |
| TGACCTY_V$ERR1_Q2 | 1.59E-05 | Genes with promoter regions [−2 kb, 2 kb] around transcription start site containing the motif TGACCTY which matches annotation for ESRRA: estrogen-related receptor alpha |
| HSA04512_ECM_RECEPTOR_INTERACTION | 1.08E-04 | Genes involved in ECM-receptor interaction |
| BRENTANI_SIGNALING | 1.06E-04 | Cancer related genes involved in the cell signaling |
| CELL_ADHESION | 3.70E-04 | The attachment of a cell, either to another cell or to the extracellular matrix, via cell adhesion molecules. |
| HSA04012_ERBB_SIGNALING_PATHWAY | 1.11E-03 | Genes involved in ErbB signaling pathway |