Table 1.
Selected proteins implicated in preventing or correcting merotelic attachments
Protein name | Proposed roles | Organism studied | Reference |
---|---|---|---|
Pcs1, Mde4 | Clamping together microtubule attachment sites | Fission yeast (S. pombe) | [28–30] |
Clr4, Swi6 | Establishment of centromeric heterochromatin | Fission yeast (S. pombe) | [29,30] |
Rad21 | Mediates sister chromatid cohesion | Fission yeast (S. pombe) | [19] |
Aurora B | Kinetochore assembly and correction of erroneous kinetochore attachments | Fission yeast (S. pombe), rat kangaroo (Potorous tridactylis) | [43,96,97] |
MCAK, Kif2b | Depolymerization of microtubules | Man (Homo sapiens), rat kangaroo (P. tridactylis), Chinese hamster (Cricetulus griseus) | [4,36,98] |
Hec1/Ndc80 | Mediates microtubule–kinetochore attachment | Rat kangaroo (P. tridactylis) | [52] |
pRB | Negative regulator of cell proliferation, chromatin compaction | Man (H. sapiens) | [14] |
Dido | Histone H3 lysine 4-binding protein | Mouse (Mus musculus) | [76] |