Table 1.

Comparison of effect of factors on myelination and remyelination.

Factor	Action on OPCs	Myelination in vitro co-cultures	Remyelination in slices	Remyelination in vivo (myelin toxin model)
PDGF	↑ Proliferation	↓ Myelination (Wang et al., 2007)	↔	↑ OPC numbers but remyelination ↔ (Woodruff et al., 2004)
FGF2	↑ Proliferation	↓ Myelination (Wang et al., 2007)	↔	Not known
NRG1	↑ Proliferation and survival	↑ Myelination (Wang et al., 2007)	↔	Remyelination ↔ (Penderis et al., 2003)
Inhibition of γ-secretase/Notch-1 ablation	↑ Differentiation	↑ Myelination (Watkins et al., 2008)	↔	Remyelination ↔ with Notch-1 ablation (Stidworthy et al., 2004)
9-cis retinoic acid	↑ Differentiation	↔ Myelination (Huang et al., 2011)	↑	↑ Remyelination (Huang et al., 2011)