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Schematic view of the talin activation cycle (after (44)). (Step 1) Talin in its inactivated state (ϕc) in the cytosol. (Step 2) Talin is recruited at the membrane (ϕm) and is activated by binding to PIP2. In this activated state, ϕ, talin interacts with the integrins (Step 3). The equilibrium between activated talin ϕ and the integrin (the bound complex is denoted ϕI) is crucial. (Step 4) Talin unbinds from the integrin and goes back to its cytosolic state (ϕc).
