Table 2.
MM Subpopulation | n | Minor Allele | Patient Frequency | Control Frequency | Odds Ratio (95%CI) | P Value 2-Sided |
---|---|---|---|---|---|---|
All MM patients | 457 | 10 bp del | 0.454 | 0.392 | 1.24 (0.98-1.56) | .07 (NS) |
Cauc Amer | 172 | 10 bp del | 0.515 | 0.401 | 1.23 (1.05-1.45) | .0148 |
Mex Amer | 285 | 10 bp del | 0.401 | 0.374 | 1.046 (0.92-1.19) | .5485(NS) |
Lesion level ≥L1 | 137 | 10 bp del | 0.427 | 0.387 | 1.07 (0.94-1.22) | .3332(NS) |
Lesion level <L1 | 320 | 10 bp del | 0.451 | 0.387 | 1.12 (1.00-1.24) | .0498 |
Cauc Amer (≥L1) | 53 | 10 bp del | 0.500 | 0.401 | 1.20 (0.96-1.50) | .1131 (NS) |
Cauc Amer (<L1) | 119 | 10 bp del | 0.521 | 0.401 | 1.25 (1.05-1.49) | .0151 |
Mex Amer (≥L1) | 84 | 10 bp del | 0.381 | 0.374 | 1.01 (0.86-1.19) | .9133 (NS) |
Mex Amer (<L1) | 201 | 10 bp del | 0.410 | 0.374 | 1.06 (0.93-1.22) | .4190 (NS) |
Abbreviations: NS, not significant; MM, myelomeningocele; Cauc Amer, Caucasian American; Mex Amer, Mexican American.
a Mex Amer controls N = 92, Cauc Amer controls N = 93, Combine controls N = 185. The minor allele (10 bp del, ATTTCTCACC) shows increased risk for some MM subpopulations (Bold).
b Cauc Amer = Caucasian American; Mex Amer = Mexican American.