Table 3.
Genetic associations comparing premature infants (<32 weeks gestation and <1,500 grams) without IVH to those with grades I–II and those with grades III–IV.
| Full data (n=271) | No IVH (n=207) | IVH grade I & II (n=38) | IVH grade III & IV (n=26) | ‡p No IVH vs grade I & II | ‡p No IVH vs grade III & IV | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Gene | rs# (A/B) | AA | AB | BB | †F_A | AA | AB | BB | †F_A | AA | AB | BB | †F_A | Genotype | Allele | Genotype | Allele |
| IL-1β | rs1143627 (C/T) | 30 | 81 | 80 | 0.37 | 6 | 18 | 6 | 0.50 | 8 | 9 | 6 | 0.54 | 0.06 | 0.06 | 0.07 | 0.03 |
| IL-6 | rs2069832 (A/G) | 18 | 70 | 81 | 0.31 | 5 | 9 | 13 | 0.35 | 1 | 12 | 10 | 0.30 | 0.41 | 0.64 | 0.52 | 1.00 |
| IL-4 | rs2243270 (A/G) | 94 | 52 | 10 | 0.77 | 16 | 8 | 0 | 0.83 | 15 | 3 | 2 | 0.83 | 0.62 | 0.36 | 0.17 | 0.55 |
| IL-10 | rs1800896 (A/G) | 54 | 103 | 42 | 0.53 | 12 | 18 | 7 | 0.57 | 4 | 17 | 4 | 0.50 | 0.80 | 0.61 | 0.35 | 0.76 |
| TNF | rs1800629 (A/G) | 5 | 45 | 142 | 0.14 | 0 | 10 | 23 | 0.15 | 0 | 9 | 16 | 0.18 | 0.59 | 0.85 | 0.39 | 0.52 |
| FII | rs1799963 (A/G) | 0 | 4 | 176 | 0.01 | 0 | 1 | 33 | 0.01 | 0 | 2 | 20 | 0.05 | 0.58 | 0.58 | 0.13 | 0.13 |
| FV | rs6025 (G/A) | 188 | 6 | 0 | 0.98 | 27 | 7 | 0 | 0.90 | 24 | 1 | 0 | 0.98 | 1.0×10−3* | 1.0×10−3* | 0.58 | 0.58 |
| FXIII | Rs5985 (G/T) | 49 | 29 | 5 | 0.77 | 10 | 3 | 0 | 0.88 | 9 | 1 | 1 | 0.86 | 0.59 | 0.21 | 0.18 | 0.42 |
| ITGB3 | rs5918 (C/T) | 4 | 51 | 117 | 0.17 | 0 | 7 | 23 | 0.12 | 0 | 5 | 17 | 0.11 | 0.75 | 0.35 | 0.77 | 0.40 |
| ESR1 | rs2234693 (C/T) | 44 | 93 | 48 | 0.49 | 10 | 14 | 9 | 0.52 | 4 | 12 | 7 | 0.43 | 0.65 | 0.79 | 0.77 | 0.53 |
| ¶Data with exclusions (n=103) | No IVH (n=81) | IVH grade I & II (n=14) | IVH grade III (n=8) | ‡p No IVH vs grade I & II | ‡p No IVH vs grade III | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Gene | rs# (A/B) | AA | AB | BB | †F_A | AA | AB | BB | †F_A | AA | AB | BB | †F_A | Genotype | Allele | Genotype | Allele |
| IL-1β | rs1143627 (C/T) | 11 | 25 | 38 | 0.32 | 1 | 7 | 3 | 0.41 | 1 | 4 | 1 | 0.50 | 0.15 | 0.47 | 0.19 | 0.21 |
| IL-6 | rs2069832 (A/G) | 10 | 31 | 24 | 0.39 | 2 | 5 | 4 | 0.41 | 0 | 4 | 3 | 0.29 | 1.00 | 1.00 | 0.75 | 0.57 |
| IL-4 | rs2243270 (A/G) | 43 | 21 | 0 | 0.84 | 7 | 3 | 0 | 0.85 | 7 | 0 | 0 | 1.00 | 1.00 | 1.00 | 0.10 | 0.13 |
| IL-10 | rs1800896 (A/G) | 20 | 40 | 19 | 0.51 | 2 | 8 | 3 | 0.46 | 0 | 6 | 1 | 0.43 | 0.80 | 0.83 | 0.26 | 0.78 |
| TNF | rs1800629 (A/G) | 2 | 13 | 61 | 0.11 | 0 | 4 | 7 | 0.18 | 0 | 4 | 4 | 0.25 | 0.41 | 0.31 | 0.11 | 0.12 |
| FII | rs1799963 (A/G) | 0 | 2 | 70 | 0.01 | 0 | 1 | 12 | 0.04 | 0 | 1 | 5 | 0.08 | 0.40 | 0.39 | 0.22 | 0.22 |
| FV | rs6025 (G/A) | 77 | 1 | 0 | 0.99 | 8 | 3 | 0 | 0.86 | 8 | 0 | 0 | 1.00 | 5.0×10−3* | 6.0×10−3 | 1.00 | 1.00 |
| FXIII | Rs5985 (G/T) | 20 | 15 | 0 | 0.79 | 3 | 1 | 0 | 0.88 | 3 | 0 | 0 | 1 | 0.63 | 1.00 | 0.26 | 0.59 |
| ITGB3 | rs5918 (C/T) | 2 | 25 | 43 | 0.21 | 0 | 4 | 6 | 0.20 | 0 | 4 | 3 | 0.29 | 1.00 | 1.00 | 0.52 | 0.50 |
| ESR1 | rs2234693 (C/T) | 17 | 36 | 20 | 0.48 | 6 | 5 | 2 | 0.65 | 3 | 0 | 4 | 0.43 | 0.29 | 0.14 | 0.02 | 0.79 |
F_A is the allele frequency of the A allele.
p is calculated with Fisher's exact test comparing infants with no documented IVH to those with documented IVH grades I–II and grades III–IV. There were no infants with grade IV IVH after exclusions, so comparisons are only made with IVH grade III.
Infants of women with heart disease, bleeding disorder, autoimmune disease, thrombocytopenia, gestational diabetes, type I diabetes, type II diabetes, chronic hypertension, pre-eclampsia, eclampsia, gestational hypertension, HELLP syndrome, infants with congenital anomalies, infants who were a twin or triplet and infants with one or both parents of non-Caucasian descent were excluded from analysis leaving samples size of 103 infants.
Significant after correction for multiple testing with Bonferroni (threshold of 5×10−3).