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Chemotherapeutic drugs restore TRAIL sensitivity at the DISC level. (a) control HeLa cells (H-Ctl), (b) TRAIL-R4 expressing HeLa cells (H-TRAIL-R4) or (c) VAL cells were pre-treated with CDDP, VP16 or 5FU or left untreated as described in Figure 1, then stimulated with TRAIL for the indicated time. TRAIL DISC was immunoprecipitated (see Materials and Methods section) and analyzed by western blot. Molecular size markers are shown on the right in kDa
