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. Author manuscript; available in PMC: 2012 May 20.
Published in final edited form as: FEBS Lett. 2011 Apr 28;585(10):1427–1434. doi: 10.1016/j.febslet.2011.04.048

Figure 2.

Figure 2

The contribution of response elements to clock gene expression is depicted. Certain genes are dominated by E-box input, e.g. Rev-erb-alpha or DBP. Other genes are dominated by RORE input, e.g. Bmal1. Many genes integrate input from both elements, e.g. Cry1 or Per2. Other elements also contribute – the CRE and D-box elements are notable examples. In this model, like a synaptic weight, all genes have the potential to get input from all transcriptional complexes, but do so to a greater or lesser extent depending on the complex.