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Morphological assessment of neuroprotective effects of compounds III and V. After glutamate treatment, granule cells were stained with Hoeschst dye to detect chromatin condensation, a hallmark of apoptosis (A), or with calcein-AM for viable cells (B). At 50 µM, both compounds III and V almost completely blocked glutamate-induced chromatin condensation and loss of viable neurons. Scale bar, 20 µm; arrows, apoptotic cells.
