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. Author manuscript; available in PMC: 2011 Jun 17.
Published in final edited form as: Neurosci Lett. 2010 Apr 13;476(3):127–132. doi: 10.1016/j.neulet.2010.04.013

Table 1.

Chemical structures, teratogenic effects, and HDAC inhibition potencies for VPA and its derivatives. Data are derived from a previous publication [7]. Teratogenic potential ranges from 0 to +++++, while acetylated histone H4 (Ac-H4) ranges from 0 to ++. HDAC blocking potencies for the five compounds are approximately correlated with their abilities to induce histone hyperacetylation and teratogenesis.

Compounds and
Structures		 Teratogenic
Potential		 AC-H4
(o to ++)		 HDAC IC50
(µM)
graphic file with name nihms203262t1.jpg +++ + 398±50
graphic file with name nihms203262t2.jpg 0 0 >10,000
graphic file with name nihms203262t3.jpg +++++ ++ 48±12
graphic file with name nihms203262t4.jpg +++ + 869±183
graphic file with name nihms203262t5.jpg +++++ ++ 13±2