Table 1.
Patients’ characteristics. Values are percentages (numbers) unless stated otherwise
| Planned non-invasive | Planned invasive (n=13 408) | |||
|---|---|---|---|---|
| Ticagrelor (n=2601) | Clopidogrel (n=2615) | Total (n=5216) | ||
| Demographics | ||||
| Median (IQR) age (years) | 66 (57-73) | 65 (57-73) | 65 (57-73) | 61 (53-69) (n=13 406) |
| Age ≥75 years | 21.3 (553) | 21.2 (555) | 21.2 (1108) | 13.2 (1770) |
| Women | 36.9 (961) | 36.1 (945) | 36.5 (1906) | 25.2 (3382) |
| Median (IQR) weight (kg) | 78 (69-88) (n=2597) | 78 (69-88) (n=2608) | 78 (69-88) (n=5205) | 80 (70-90) (n=133 63) |
| Median (IQR) body mass index (kg/m2) | 27.3 (24.6-30.4) (n=2592) | 27.4 (24.6-30.4) (n=2603) | 27.3 (24.6-30.4) (n=5195) | 27.4 (24.8-30.4) (n=133 37) |
| Cardiovascular risk factors | ||||
| Habitual smoker | 25.2 (654/2600) | 25.8 (675/2614) | 25.5 (1329/5214) | 39.9 (5349/13 396) |
| Hypertension | 71.8 (1868/2600) | 72.4 (1893) | 72.1 (3761/5215) | 62.9 (8422/13 398) |
| Dyslipidaemia | 47.0 (1223/2600) | 45.5 (1191) | 46.3 (2414/5215) | 46.8 (6275/13 397) |
| Diabetes mellitus | 30.6 (796/2600) | 28.9 (757) | 29.8 (1553/5215) | 23.2 (3109/13 398) |
| Medical history | ||||
| Angina pectoris | 59.5 (1547/2600) | 58.7 (1536) | 59.1 (3083/5215) | 39.4 (5275/13 398) |
| Myocardial infarction | 28.9 (752/2600) | 30.3 (793) | 29.6 (1545/5215) | 17.0 (2279/13 398) |
| Congestive heart failure | 11.2 (290/2600) | 12.4 (324) | 11.8 (614/5215) | 3.3 (436/13 398) |
| Percutaneous coronary intervention | 12.5 (325/2600) | 12.8 (335) | 12.7 (660/5215) | 13.7 (1832/13 397) |
| Coronary artery bypass graft | 6.7 (175/2600) | 7.4 (194) | 7.1 (369/5215) | 5.5 (737/13 398) |
| Transient ischaemic attack | 3.9 (101/2600) | 4.2 (110) | 4.0 (211/5215) | 2.1 (288/13 398) |
| Non-haemorrhagic stroke | 5.5 (144/2600) | 5.8 (151/2614) | 5.7 (295/5214) | 3.2 (427/13 398) |
| Peripheral arterial disease | 7.3 (191/2600) | 8.0 (210) | 7.7 (401/5215) | 5.5 (743/13 398) |
| Chronic renal disease | 5.0 (131/2600) | 5.5 (143) | 5.3 (274/5215) | 3.8 (511/13 398) |
| Physical findings | ||||
| Median (IQR) heart rate | 72 (64-82) (n=2584) | 73 (65-82) (n=2601) | 72 (64-82) (n=5185) | 74 (64-84) (n=13 231) |
| Median (IQR) systolic blood pressure | 130 (120-150) (n=2584) | 130 (120-150) (n=2601) | 130 (120-150) (n=5185) | 133 (120-150) (n=13 231) |
| Median (IQR) diastolic blood pressure | 80 (70-88) (n=2584) | 80 (70-86) (n=2601) | 80 (70-87) (n=5185) | 80 (70-90) (n=13 231) |
| Risk indicators | ||||
| Troponin positive* | 74.5 (1860/2495) | 75.4 (1900/2520) | 75.0 (3760/5015) | 86.9 (11 329/13 042) |
| ST depression (≥1 mm) | 61.7 (1602/2597) | 64.0 (1673/2613) | 62.9 (3275/5210) | 46.4 (6211/13 380) |
| TIMI NSTE-ACS risk score >2 | 89.2 (2259/2532) | 88.5 (2261/2555) | 88.9 (4520/5087) | 68.8 (8954/13 006) |
IQR=interquartile range; TIMI NSTE-ACS=Thrombolysis In Myocardial Infarction non-ST elevation acute coronary syndrome.
*Positive result on testing for troponin I consisted of troponin I concentration ≥0.08 µg/L for first sample taken, as measured at central laboratory with use of Advia Centaur TnI-Ultra Immunoassay (Siemens).