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. 2011 Jun 14;27(13):i401–i409. doi: 10.1093/bioinformatics/btr206

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© The Author(s) 2011. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.5), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Fig. 3. — Network analysis of comodule 40. (A) The highly connected network consists mainly of genes in comodule 40 (orange nodes), but also includes 6 genes identified using the IPA system (white nodes). Two miRNAs (miR-222, miR-99a, green nodes) are also shown. Based on the MicroCosm Targets V5.0 dataset, miR-222 targets two genes (solid line). Significant anti-correlations between miRNAs and genes are shown with dashed lines. (B) Anti-correlations between miR-222 and gene expression profiles (Pearson's correlation coefficients <−0.21, P-value <5.0×10⁻⁵).