Skip to main content
. Author manuscript; available in PMC: 2011 Jun 17.
Published in final edited form as: Prog Mol Biol Transl Sci. 2010;97:41–78. doi: 10.1016/B978-0-12-385233-5.00002-7

FIG. 3.

FIG. 3

Notch signaling. Notch signaling is initiated when the extracellular portion of a Notch receptor contacts a Notch ligand from a signaling cell. This triggers the gamma-secretase-mediated cleavage of the intracellular domain of the engaged Notch receptor. This Notch intracellular domain (NICD) translocates to the nucleus where it complexes with Mastermind-like protein (MAML) and recombining binding protein suppressor of hairless (RBPJκ). This complex then mediates transcription of Notch target genes such as the Hes and Hey family of genes.