Table 1.

Association results of top 30 SNPs from a genomewide association study of 708 DSM-IV cannabis dependence cases and 2346 controls from SAGE. (All allele frequencies and odds-ratios reflect analysis of increasing risk associated with the reference allele).

Chromosome	SNP	Gene	Function	Overall (N=3054):				European-American (N=2019):			African-American (N=1035):
				Odds Ratio	Lower 95%	Upper 95%	P-value	Allele frequency	O.R.	P-value	Allele frequency	O.R.	P-value
1	rs9427573	UCHL5	Intron	2.557	1.71	3.822	4.75E-06	0.001	1.94	0.6318	0.06	2.47	0.00001
1	rs9427836	UCHL5	Intron	2.411	1.611	3.61	1.91E-05	0.001	1.94	0.631	0.06	2.35	0.00002
2	rs17552189		Nongenic	1.397	1.212	1.61	4.12E-06	0.38	1.33	0.00124	0.17	1.58	0.0005
2	rs2381356	KYNU	Intron	0.637	0.518	0.782	1.70E-05	0.06	0.67	0.04543	0.29	0.63	0.00014
3	rs12491921		Nongenic	1.385	1.215	1.578	1.03E-06	0.48	1.27	0.00471	0.36	1.63	0.00001
6	rs1462146	AIM1	Intron	0.514	0.381	0.692	1.16E-05	0.003	-	-	0.2	0.54	0.00004
6	rs16900973	RPS6KA2	Intron	1.595	1.284	1.982	2.48E-05	0.06	1.39	0.04809	0.12	1.71	0.00031
9	rs10858373		Nongenic	1.4	1.201	1.632	1.68E-05	0.27	1.4	0.00027	0.11	1.43	0.02477
10	rs11007350		Nongenic	0.731	0.641	0.833	2.68E-06	0.55	0.68	0.00001	0.36	0.89	0.0892
10	rs1007264	STAM	Intron	1.512	1.248	1.831	2.34E-05	0.09	1.67	0.00021	0.15	1.4	0.01665
11	rs2169487		Nongenic	1.636	1.31	2.042	1.41E-05	0.01	1.46	0.2442	0.27	1.57	0.00013
11	rs2068909		Nongenic	2.238	1.546	3.239	1.96E-05	0.0004	-	-	0.07	1.99	0.0002
11	rs1352414		Nongenic	2.736	1.721	4.349	2.07E-05	0.0004	-	-	0.05	2.53	0.00006
11	rs1609930	MICAL2	Intron	0.713	0.609	0.835	2.77E-05	0.17	0.71	0.0026	0.37	0.69	0.00102
12	rs12811699	CHST11	Intron	1.737	1.363	2.213	7.88E-06	0.02	2.03	0.02759	0.18	1.6	0.00034
12	rs12828809	CHST11	Intron	1.724	1.355	2.195	9.61E-06	0.01	2.04	0.02659	0.1832	1.59	0.00039
12	rs1280605	LGR5	Intron	0.699	0.596	0.819	1.04E-05	0.15	0.68	0.00163	0.61	0.71	0.00115
12	rs7313862	DKFZP779	Intron	1.327	1.163	1.514	2.61E-05	0.32	1.31	0.003	0.47	1.33	0.00593
12	rs555404	ACADS	Intron	0.758	0.667	0.863	2.66E-05	0.54	0.78	0.00255	0.34	0.71	0.00207
13	rs9507041		Nongenic	1.549	1.278	1.878	8.47E-06	0.11	1.53	0.00115	0.12	1.63	0.00137
13	rs7317962	KATNAL1	Intron	0.735	0.638	0.847	2.23E-05	0.39	0.72	0.00033	0.23	0.78	0.04643
14	rs17102248		Nongenic	4.291	2.19	8.405	2.19E-05	0.0002	-	-	0.02	4	0.00004
16	rs11865530	FTO	Intron	2.404	1.603	3.603	2.18E-05	0.0004	-	-	0.06	2.28	0.00005
17	rs1019238	ANKFN1	Intron	1.453	1.254	1.682	6.12E-07	0.4	1.43	0.00003	0.1	1.53	0.00828
17	rs1431318		Nongenic	0.708	0.616	0.812	9.14E-07	0.44	0.68	0.00001	0.25	0.8	0.06522
17	rs8065311		Nongenic	1.432	1.234	1.661	2.10E-06	0.4	1.4	0.00007	0.09	1.55	0.01125
17	rs9894332		Nongenic	0.748	0.657	0.852	1.25E-05	0.47	0.74	0.00032	0.36	0.81	0.04837
17	rs10521290		Nongenic	1.331	1.165	1.522	2.69E-05	0.72	0.73	0.0002	0.28	0.83	0.104
19	rs8111749		Nongenic	1.572	1.277	1.936	2.05E-05	0.05	2.06	0.00008	0.19	1.35	0.02105
22	rs28372448	PIM3	Intron	1.681	1.338	2.112	8.00E-06	0.06	1.82	0.00015	0.08	1.54	0.01367