Table 1.
Frequency of PTPN22 1858C/T alleles and genotypesin patients and healthy controlsa
| Genotype or allele | Control (N = 200) | T1D (N = 150) | GD (N = 171) | RA (N = 121) |
|---|---|---|---|---|
| N (%) | ||||
| T/T | 2 (1) | 11 (7) | 7 (4) | 2 (2) |
| C/T | 66 (33) | 40 (27) | 49 (29) | 38 (31) |
| C/C | 132 (66) | 99 (66) | 115 (67) | 81 (67) |
| P | - | <0.001 | <0.05 | NS c |
| OR (95% CI) b | - | 7.84 (1.71-35.90) | 4.23 (0.87-20.62) | 3.50 (0.74-16.70) |
| Allele T | 70 (17.5) | 62 (20.5) | 63 (18) | 42 (17) |
| Allele C | 330 (82.5) | 238 (79.5) | 279 (82) | 200 (83) |
| P | - | NS | NS | NS |
a
values are the frequency (number) of genotypes/alleles. P values were tested using x2 test for each patient group vs control group.
b
the odds ratios (ORs) and 95% confidence intervals (95% CIs) are for carriage of TT versus CT+CC genotypes.
c
not significant