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Inhibition by PD98059 (50 μM) and/or LY984002 (100 μM) of the EPO (0.3 units/ml) induced neuroprotection in rat hippocampal neurons upon hypoxia. ○, level of spontaneous cell death of rat hippocampal neurons under normoxia; •, level of cell death upon 15 h of hypoxia. (Data represent mean ± SD. *, P < 0.05; **, P < 0.01 compared with hypoxia alone; n = 4–5.)
