Table 1.
Baseline subject characteristics
| Median | Range | |
| Age (years) | 49.9 | 32.0 - 55.2 |
| Gender (M:F) | 6:1 | |
| Time since HIV diagnosis (years) | 17.0 | 1.7 - 20.3 |
| HIV-1 RNA (log10 copies/mL) | ||
| Plasma | 4.49 | 4.26 - 5.56 |
| CSF | 3.87 | 3.11 - 4.47 |
| Plasma:CSF difference | 1.06 | 0.12 - 1.58 |
| Blood T cells (cells/μL) | ||
| CD4+ | 453 | 267 - 806 |
| CD8+ | 1,009 | 575 - 2185 |
| CSF WBCs (cells/μL) | 9 | 2 - 18 |
| Neopterin (nmol/L) | ||
| CSF | 13.1 | 5.9 - 41.2 |
| Plasma | 13.4 | 9.2 - 53.5 |
| CSF CCL2 (pg/mL) | 479.2 | 397.9 - 1322.2 |
| T Cell Activation (percent CD38+/HLA-DR+) | ||
| CSF CD4+ | 14.7 | 3.4 - 60.2 |
| Blood CD4+ | 13.3 | 7.6 - 24.7 |
| CSF CD8+ | 83.4 | 41.8 - 97.6 |
| Blood CD8+ | 58.5 | 34.5 - 78.0 |
| Monocyte Activation (percent CD16+) | ||
| CSF monocytes | 93.6 | 80.1 - 100 |
| Blood monocytes | 10.8 | 4.7 - 17.0 |
| CSF:blood albumin ratio | 5.05 | 3.91 - 12.26 |
| QNPZ-4 | -0.32 | -3.44 - 0.54 |