Figure 5.

Measured concentrations and simulated fits of Atorvastatin compounds, individual 3. Displayed are the measured concentrations (rhombs) with mean and standard deviation (n = 3) of Atorvastatin compounds in the culture medium (upper two rows) and free Atorvastatin compounds inside primary hepatocytes (lower two rows) of individual 3, and corresponding simulation profiles (solid lines and dashed lines). First and third row: AS (left), ASpOH (middle) and ASoOH (right). Second and fourth row: ASL (left), ASLpOH (middle) and ASLoOH (right). The dashed lines show the additional consideration of putative beta-oxidation of atorvastatin acids, AS, ASpOH and ASoOH, and of adaptation of CYP3A4 and UGT1A3 protein concentrations in the model fit.