Table 3.
SNP-SNP interaction included in final multivariable model
| Interaction | R 2 | Adjusted R 2 | ΔR 2 | Standardized beta | ||
|---|---|---|---|---|---|---|
| Coefficients | t | P | ||||
| CAG | .730 | .729 | -.864 | -34.23 | <0.0001 | |
| NRF-1 rs6949152 * CO1 C7028T | .739 | .738 | .009 | -.090 | -3.55 | <0.0001 |
| NRF-1 rs7781972 * TFAM rs11006132 | .745 | .743 | .014 | -.077 | -3.03 | <0.003 |
| PPARGC1A rs7665116 | .749 | .747 | .018 | -.069 | -2.72 | <0.007 |
A multivariable model including a total of four interactions was built in the total HD cohort using forward selection. With the addition of each SNP-SNP interaction, along with each SNP's respective main effect, the variability in adjusted log motor AO increased (assessed by adjusted R2). The final multivariable model explains 4.8% additional residual variance in HD motor AO.