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Calculated (Q(a,ζH)/Q(a,ζD)) and experimental kinetic deuterium isotope effects at 20 C for the hydride transfer catalyzed by Escherichia coli dihydrofolate reductase in various solvents
| Solvent | a | KIEa | KIEexp |
|---|---|---|---|
| H2O | 1 | 7.15 | 2.70 |
| MeOH 17% | 24 | 2.25 | 2.73 |
| MeOH 33% | 1 | 7.15 | 2.60 |
| MeOH 50% | 1 | 7.15 | 2.70 |
| glycerol 17% | 1 | 7.15 | 2.65 |
| glycerol 33% | 96 | 1.37 | 2.65 |
| glycerol 50% | 169 | 1.23 | 2.66 |
| sucrose 17% | 3 | 5.68 | 3.13 |
| sucrose 30% | 108 | 1.22 | 3.22 |
The corresponding TST value is 7.15.
