Figure 7. Analysis of differentially expressed miRNA species present in gender specific categories.

(A) Comparison of observed versus the expected scores obtained by SAM analysis of all 534 features from 8 males and 10 Caucasian females. Each feature is represented by an open circle, and the differentially expressed features represented as red points in the graph. The dashed lines represent a FDR threshold of 5%. (B) Distributions of normalized log₂ signal intensities of 4 differentially expressed features in males (M1–M8; blue) and females (F1–F10; red). (C) Hierarchical clustering of samples (males in blue: M1–M8 and females in red: F1–F10) based on summarized intensity values from the 4 differentially expressed circulating miRNAs. The log₂ intensity values are shown in the bar scale.