Figure 8. A model depicting the possible olig2 regulation mechanism by Pax6.

(a) In this model, Pax6 protein represses the olig2 gene by binding on the olig2 promoter region. This binding either could inhibit the binding to an activator to the HEB binding site or recruit a repressor to the HEB site. Either would inhibit olig2 and promote neurogenesis. (b)Without Pax6, unknown activator complex is recruited and activates olig2 transcription, leading to higher Olig2 levels and gliogenesis.