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. 2011 May 31;12:276. doi: 10.1186/1471-2164-12-276

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Copyright ©2011 Sun et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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The degree of genes regulated by miRNAs is negatively correlated with their evolutionary rate in rESCs. (A): The correlation coefficient (r = -0.564 with P = 0.018 based on Pearson's correlation) between dN/dS ratios and degrees of genes regulated by miRNAs in rESCs; (B): The correlation coefficient (r = -0.556 with P = 0.039 based on Pearson's correlation) between dN/dS ratios and degrees with normalization of 3'UTR length per 1 kb; (C): The correlation coefficient (r = -0.533 with P = 0.019 based on Pearson's correlation) between dN/dS ratios and degrees with normalization of 3'UTR length per 2 kb; (D): The degree of miRNAs and their targets in the random network is significantly lower (p < 2.2e^-16with a Wilcoxon rank sum test) compared with those in the MT network.