Figure 2. Poly(I:C)-electroporated tumor cells are more susceptible to NK cell-mediated killing compared to mock-electroporated tumor cells.
Percentage killing of mock- and poly(I:C)-electroporated tumor cell lines K562 and U-937 by purified NK cells based on the viability (annexin V− PI−) of PKH67+ target cells. Cocultures were kept overnight at a 1∶1 NK:tumor cell ratio. Horizontal lines represent mean of 8 donors. Differences are statistically significant if p<0.05. Abbreviations: mock EP, electroporated without poly(I:C); pIC EP, electroporated with poly(I:C).