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. 2011 Jun 17;6(6):e21120. doi: 10.1371/journal.pone.0021120

Table 5. The cumulative effects of unfavorable genotypes on survival.

Chemotherapy						Chemoradiation
No. of unfavorable genotypes	No. dead/alive	HR^* (95% CI)	P value	MST^#	Log-rank P value	No. of unfavorable genotypes	No. dead/alive	HR^* (95% CI)	P value	MST^#	Log-rank P value
0	42/18	Reference		18.22		0–1	15/12	Reference		39.80
1–2	164/31	1.69(1.19–2.41)	0.004	11.22		2–3	67/16	3.48(1.70–7.11)	0.001	13.22
3–4	89/11	2.52(1.71–3.71)	<0.001	8.19	<0.0001	4–5	22/4	5.07(2.04–12.64)	<0.001	12.37	0.0119
			P_trend<0.001						P_trend<0.001

*HR adjusted by age, gender, ethnicity, smoking status and pack-years, performance status, clinical stage.

#MST, median survival time (months)