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. 2011 Jun 17;6(6):e21131. doi: 10.1371/journal.pone.0021131

Figure 2. The DMSPN is a bipartite network.

Figure 2

The circles and rectangles in the network correspond to diseases and metabolic subpathways respectively. A disease and a subpathway are connected by an edge if the set of disease genes are statistically significantly enriched to the corresponding subpathway. Node size is proportional to the degree of the node. Nodes are colored according to their categories, which include 18 disease classes from the Genetic Association Database (GAD) for disease nodes and 11 subpathway classes from the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway database for metabolic subpathway nodes. Edges are colored according to the enrichment significance (P-values) of associations between diseases and subpathways.