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. Author manuscript; available in PMC: 2011 Jun 17.
Published in final edited form as: Ann Biomed Eng. 2010 Mar 11;38(7):2346–2357. doi: 10.1007/s10439-010-9993-6

TABLE 1.

Periodic QTc assessment.

dpr (days) 0 3 10 17 24 31 38 45 52 59
QTc control (ms) 347 ± 41 320 ± 32 337 ± 47 289 ± 32 326 ± 43 325 ± 60 299 ± 14 348 ± 64 311 ± 24 325 ± 42
QTc no scar (ms) 306 ± 17 495 ± 57 541 ± 18 521 ± 54 554 ± 11 535 ± 27 545 ± 15 528 ± 53 530 ± 48 496 ± 31
QTc scarred (ms) 322 ± 18 450 ± 65 472 ± 67 577 ± 37 499 ± 45 502 ± 10 531 ± 18 527 ± 41 543 ± 55 534 ± 51
p value for one-way ANOVA test 0.158 0.001 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000
p value for t-test (control vs. scarred) 0.655 0.034 0.070 0.000 0.007 0.000 0.000 0.002 0.013 0.015
p value for t-test (control vs. no scar) 0.200 0.007 0.000 0.000 0.000 0.000 0.000 0.002 0.001 0.000
p value for t-test (no scar vs. scarred) 0.431 0.429 0.211 0.160 0.163 0.081 0.344 0.992 0.752 0.339

Periodic mean QTc intervals of fish undergoing ventricular resection were compared with the sham over 59 days. The differences in QTc intervals between the sham and resected ventricles were statistically significant starting at 3 dpr (p<0.05, n = 4 and 3, respectively). However, the QTc values between regeneration and scar tissues were statistically insignificant (p>0.05, n = 4 and 3, respectively).