TABLE 1.
Periodic QTc assessment.
dpr (days) | 0 | 3 | 10 | 17 | 24 | 31 | 38 | 45 | 52 | 59 |
---|---|---|---|---|---|---|---|---|---|---|
QTc control (ms) | 347 ± 41 | 320 ± 32 | 337 ± 47 | 289 ± 32 | 326 ± 43 | 325 ± 60 | 299 ± 14 | 348 ± 64 | 311 ± 24 | 325 ± 42 |
QTc no scar (ms) | 306 ± 17 | 495 ± 57 | 541 ± 18 | 521 ± 54 | 554 ± 11 | 535 ± 27 | 545 ± 15 | 528 ± 53 | 530 ± 48 | 496 ± 31 |
QTc scarred (ms) | 322 ± 18 | 450 ± 65 | 472 ± 67 | 577 ± 37 | 499 ± 45 | 502 ± 10 | 531 ± 18 | 527 ± 41 | 543 ± 55 | 534 ± 51 |
p value for one-way ANOVA test | 0.158 | 0.001 | 0.000 | 0.000 | 0.000 | 0.000 | 0.000 | 0.000 | 0.000 | 0.000 |
p value for t-test (control vs. scarred) | 0.655 | 0.034 | 0.070 | 0.000 | 0.007 | 0.000 | 0.000 | 0.002 | 0.013 | 0.015 |
p value for t-test (control vs. no scar) | 0.200 | 0.007 | 0.000 | 0.000 | 0.000 | 0.000 | 0.000 | 0.002 | 0.001 | 0.000 |
p value for t-test (no scar vs. scarred) | 0.431 | 0.429 | 0.211 | 0.160 | 0.163 | 0.081 | 0.344 | 0.992 | 0.752 | 0.339 |
Periodic mean QTc intervals of fish undergoing ventricular resection were compared with the sham over 59 days. The differences in QTc intervals between the sham and resected ventricles were statistically significant starting at 3 dpr (p<0.05, n = 4 and 3, respectively). However, the QTc values between regeneration and scar tissues were statistically insignificant (p>0.05, n = 4 and 3, respectively).