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. Author manuscript; available in PMC: 2012 Jun 1.
Published in final edited form as: Ann Neurol. 2011 Mar 17;69(6):975–985. doi: 10.1002/ana.22367

Figure 2.

Figure 2

Repetitive hypoxic preconditioning (RHP) promotes long-lasting neurovascular protection. (A and B) RHP reduced (A) infarct volume, and (B) hemispheric swelling following tMCAo in animals with RHP completed 2 days though 8 wks prior to tMCAo (n=6–10/group) versus control animals with tMCAo but no prior RHP (n=9). Individual values (black-filled circles), mean (black horizontal bars), and values (open circles) that fell outside of the 95% confidence interval (gray boxes) are given. (C) Representative TTC-stained coronal sections from groups shown in (A) of the infarct volume closest to the mean. (D) RHP 2 wks prior to pMCAo reduced infarct volume (n=10) compared to control animals with pMCAo but no prior RHP (n=16). SHP was protective only when pMCAo followed SHP at1 day (n=13), but not 2 wks (n=9). (E) Corresponding hemispheric swelling in mice subjected to pMCAo. *p<0.05, **p<0.01, ***p<0.001 vs. Control.