Table 1.

Physiologic parameters of repetitive hypoxic preconditioning (RHP)

	(n)	pH	PaCO2(mm Hg)	PaO2(mmHg)	MABP(mmHg)	Glucose(mg/dL)
Sham Surgery
	(7)	7.27 ± 0.02	35 ± 2	1 05 ± 9	57 ± 2	352 ± 47
Control transient MCAo
	(5)	7.25 ± 0.01*	45 ± 2	78 ± 9	65 ± 11	244 ± 39
RHP + transient MCAo
2 days	(6)	7.23 ± 0.03	45 ± 3	90 ± 5	82 ± 10	300 ± 46
2 wks	(6)	7.32 ± 0.02	36 ± 3	102 ± 4	64 ± 5	259 ± 26
4 wks	(5)	7.13 ± 0.08†	36 ± 9	110 ± 14†	70 ± 19	259 ± 26
Control TNFα
	(9)	7.34 ± 0.02*	29 ± 2	90 ± 4	61 ± 2	273 ± 29
RHP + TNFα
2 days	(5)	7.3 ± 0.04	33 ± 4	105 ± 10	62 ± 6	322 ± 31
2 wks	(6)	7.30 ± 0.02	32 ± 2	86 ± 9	56 ± 2	224 ± 33
4 wks	(4)	7.26 ± 0.04†	35 ± 7	91 ± 5	75 ± 10*†	295 ± 55
Control permanent MCAo
	(9)	7.28 ± 0.02	43 ± 6*	105 ± 5	79 ± 2*	158 ± 19*
SHP + permanent MCAo
1 day	(9)	7.32 ± 0.02	38 ± 1	100 ± 6	80 ± 4*	133 ± 25*
2 wks	(5)	7.29 ± 0.04	47 ± 6*	100 ± 11	72 ± 9	173 ± 17*
RHP + permanent MCAo
2 wks	(6)	7.35 ± 0.02*†	44 ± 2*	100 ± 6	75 ± 5*	217 ± 30*

All values (mean ± SEM) were measured 24h after MCAo or 4h after TNF-α; PaCO₂, arterial PCO₂; PaO₂, arterial PO₂; MABP, mean arterial blood pressure; tMCAo, transient middle cerebral artery occlusion; RHP, repetitive hypoxic preconditioning; SHP, single hypoxic preconditioning.

^*p<0.05 vs. sham;

^†p<0.05 vs. control