Table 2.
Cerebral blood flow and neurological deficits following tMCAo in mice receiving repetitive hypoxic preconditioning (RHP) 2 days to 8 wks earlier
| Analysis | (n) | CBF ischemia* | CBF reperfusion | CBF 24h | NDS 15 min | NDS 24h |
|---|---|---|---|---|---|---|
| Control tMCAo | ||||||
| (9) | 7 ± 1 | 97 ± 6 | 89 ± 10 | 1.7 ± 0.4 | 1.9 ± 0.5 | |
| RHP + 2 day | ||||||
| (8) | 5 ± 0 | 96 ± 4 | 102 ± 3 | 1.8 ± 0.5 | 1.4 ± 0.6 | |
| RHP + 2 wks | ||||||
| (10) | 5 ± 0 | 104 ± 4 | 102 ± 3 | 1.7 ± 0.3 | 1.2 ± 0.3 | |
| RHP + 4 wks | ||||||
| (7) | 6 ± 1 | 105 ± 5 | 106 ± 4 | 1.8 ± 0.5 | 1.6 ± 0.6 | |
| RHP + 8 wks | ||||||
| (6) | 5 ± 1 | 113 ± 5† | 107 ± 4 | 1.8 ± 0.3 | 1.6 ± 0.4 | |
Values are mean (SEM). CBF values are shown as a percent of baseline.; CBF, cerebral blood flow; NDS, Neurological deficit score; tMCAo, transient middle cerebral artery occlusion; RHP, repetitive hypoxic preconditioning;
*
all groups p<0.05 vs. baseline;
†
p<0.05 vs. baseline.