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. Author manuscript; available in PMC: 2013 Jan 1.
Published in final edited form as: Addict Biol. 2011 Feb 11;17(1):108–120. doi: 10.1111/j.1369-1600.2010.00284.x

Figure 6.

Figure 6

Schematic diagram linking genes that were targeted for functional validation using null mutant mice. The diagram is based on existing pathways from KEGG (http://www.genome.jp/kegg/) and BioCarta (http://www.biocarta.com/) as well as published literature (see Discussion for references). Cd14 is a key component of the Toll-like receptor pathway resulting in production of proinflammatory cytokines, such as IL-1 and IL-6. IL1RN is an antagonist for IL-1 receptor. Cathepsins S and F are cysteine proteases that degrade the invariant polypeptide of major histocompatibility complex, class II (Cd74) and promote the presentation of antigens by antigen-presenting cells. This function is served by microglia and astrocytes in brain. B2m also plays a role in antigen presentation.