Table 1.
Clinical symptom ratings for first-episode schizophrenia patients at baseline and 4 wk
| Clinical symptom | Baseline (neuroleptic naive), mean±S.D. | 4 wk (medicated), mean±S.D. | ta | d.f.a | p valueb |
|---|---|---|---|---|---|
| BPRS total score | 52.58±8.9 | 42.91±7.5 | 4.13 | 23 | <0.001b |
| BPRS symptom clusters | |||||
| Psychosis | 24.46±4.6 | 19.00±4.5 | 7.06 | 23 | <0.001b |
| Thought disturbance | 18.87±3.7 | 14.04±3.5 | 5.80 | 23 | <0.001b |
| Paranoia | 9.71±3.2 | 7.54±2.9 | 4.28 | 23 | <0.001b |
| Mood (anxiety-depression) | 18.50±6.2 | 14.71±3.9 | 2.56 | 23 | 0.017 |
| Positive symptoms (SAPS) | 24.29±11.0 | 14.21±12.1 | 4.91 | 23 | <0.001b |
| Negative symptoms (SANS) | 45.46±10.3 | 42.17±8.2 | 1.48 | 23 | 0.156 |
| Neurological symptoms – Totalc | 6.95±3.5 | 5.35±2.9 | 2.31 | 19 | 0.032 |
BPRS, Brief Psychiatric Rating Scale ; SAPS, Schedule for the Assessment of Positive Symptoms ; SANS, Schedule for the Assessment of Negative Symptoms.
a
t test, paired samples; two-tailed; d.f., degrees of freedom.
b
Bonferroni correction of standard α≤0.05≤0.00625; p≤0.10≤0.0125.
c
NES Total Subscale (Sanders et al. 2000) from Neurological Evaluation Scale (NES; Buchanan & Heinrichs, 1989).