Table 3.
Oral busulfan dose adjustments to achieve target busulfan Css according to GSTA1 haplotype
| Number of patients (Total = 95) | GSTA1 Haplotype | ||
|---|---|---|---|
| *A/*A | *A/*B | *B/*B | |
| 36 | 40 | 19 | |
| Dose 5 | 1.04 ± 0.15 | 1.01 ± 0.20 | 0.88 ± 0.13 |
| Dose 1 | (0.79–1.52) | (0.46–1.41) | (0.60–1.16) |
| Dose 9 | 1.02 ± 0.09 | 1.02 ± 0.09 | 1.00 ± 0.07 |
| Dose 5 | (0.88–1.24) | (0.80–1.23) | (0.91–1.14) |
Data are presented as mean ± standard deviation (range). Busulfan dose 1 was 1 mg/kg for all patients; doses 5 and 9 were adjusted to achieve target Css.