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. Author manuscript; available in PMC: 2012 Jun 1.
Published in final edited form as: Ann Neurol. 2011 Mar 17;69(6):954–962. doi: 10.1002/ana.22348

Figure 3. VEGF induced focal angiogenesis in the normal brain and dysplastic vessel formation in the Alk1-deleted brain.

Figure 3

(A) Representative images show lectin-perfused vessels in the brain. Capillary density is high in all AAV-VEGF-treated groups as compared to the AAV-LacZ control group. Dilated irregular vessels were only observed in the brain with Alk1 deletion and VEGF stimulation. Scale Bar=50 µm.

(B) Bar graphs show capillary density (left) and dysplasia index (right). Capillary density increased in all groups with VEGF stimulation as compared to the AAV-lacZ control group (p=0.07). Dysplasia index increased significantly in Alk1-floxed mice treated with Ad-Cre and AAV-VEGF as compared to all other groups (p<0.01).