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. Author manuscript; available in PMC: 2012 Jun 17.
Published in final edited form as: ACS Chem Biol. 2011 Feb 28;6(6):563–572. doi: 10.1021/cb100392r

Figure 1. Structures of cysteine cathepsin activity-based probes.

Figure 1

a) Structures of the activity-based probes Cy5DCG04 and GB123 containing epoxide and AOMK reactive electrophiles, respectively (see dashed boxes). b) Structures of MGP151 (1) and MGP140 (2) and, cysteine cathepsin activity-based probes designed based on DCG-04 and GB123. Note these probes have swapped electrophiles (see dashed boxes) relative to the original DCG-04 and GB123 probes.