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TFKs influence cytokine production by CD4+ effector T cell lineages. CD4+ T cells differentiate into distinct cytokine producing effector lineages. Itk has been shown to affect Th2 and Th17 cytokine expression. Rlk/Txk has been proposed to promote expression of IFN-γ, a Th1 cytokine. The contribution of Tec to these lineages has only recently been appreciated.
