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. Author manuscript; available in PMC: 2012 Aug 1.
Published in final edited form as: Bone. 2011 Mar 31;49(2):250–256. doi: 10.1016/j.bone.2011.03.770

Fig 5.

Fig 5

Histological analysis of tibiae and femora from 44-day-old Tx-2, Tx-8.2, and untreated WT mice. (A) Alizarin red/ alcian blue staining of the tibia revealed increased bone mineralization with increased dosage (Tx-8.2) of ENB-0040, which is comparable to the WT mice. (B) Von kossa/Van Gieson staining of the femoral section also shows reduction in osteoid volume with increased dosage (Tx-8.2) of ENB-0040. Arrows indicate the presence of osteoid in Tx-2.0 group which was significantly reduced in the Tx-8.2 group and showed no significant difference from WT mice (Tx-2.0: OV/BV= 5.723%, Tx-8.2: OV/BV= 0.013%, WT: OV/BV= 0.009%. TX-8.2 versus WT: non-significant, p= 0.26).