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Distribution of radiographs of the feet, rib cage, and lower limbs of Akp2−/− mice receiving vehicle or 0.5, 2.0, or 8.2 mg/kg/day ENB-0040, displaying normal bony structures
| Number of mice with normal bony structures (%) | |||
|---|---|---|---|
| Group | Left Foot | Rib Cage | Right Lower Limb |
| Vehicle (N=20) | 2 (10) | 3 (15) | 5 (25) |
| Tx-0.5 (N=18) | 7 (39) | 7 (39) | 10 (56) |
| Tx-2.0 (N=20) | 17 (85) | 16 (80) | 16 (80) |
| Tx-8.2 (N=19) * | 19 (100) | 15 (88) | 16 (84) |
N=17 for rib cage specimens
