Table 1.
PPAR ligands. See text for details.
| Receptor | Endogenous ligands | Synthetic ligands |
|---|---|---|
| PPARα | Saturated fatty acids, unsaturated fatty acids, leukotriene B4, 8-HETE | Clofibrate, fenofibrate, gemfibrozil, Wy-14643 |
| PPARβ/δ | Saturated fatty acids, unsaturated fatty acids, 15-HETE, components of VLDLs | GW-501516 |
| PPARγ | Unsaturated fatty acids, 15d-PGJ2, 15-HETE, 9-HODE, 13-HODE, components of oxLDLs | TZDs (rosiglitazone, pioglitazone, troglitazone and ciglitazone), farglitazar, tyrosine derivatives, NSAIDs |