Table 3.
ApoD protein levels in various brain regions from normal, schizophrenic, and bipolar subjects
| Brain region | ApoD, μg/mg protein | |
|---|---|---|
| Control | Schizophrenic | |
| DLPFC | 0.127 ± 0.008 (n = 19) | 0.244 ± 0.027 (n = 20)*** |
| OC | 0.196 ± 0.013 (n = 18) | 0.201 ± 0.014 (n = 19) |
| Caudate | 0.078 ± 0.011 (n = 18) | 0.132 ± 0.021 (n = 20)* |
| SN | 0.146 ± 0.008 (n = 17) | 0.183 ± 0.019 (n = 17) |
| Hipp | 0.059 ± 0.005 (n = 17) | 0.069 ± 0.008 (n = 14) |
| Cb | 0.086 ± 0.009 (n = 18) | 0.088 ± 0.015 (n = 18) |
| Control | Bipolar | |
| DLPFC | 0.115 ± 0.015 (n = 8) | 0.233 ± 0.043 (n = 8)** |
| OC | 0.220 ± 0.028 (n = 9) | 0.205 ± 0.034 (n = 8) |
| Caudate | 0.059 ± 0.015 (n = 8) | 0.112 ± 0.018 (n = 8)* |
ApoD concentrations were measured by ELISA using purified apoD as a standard. DLPFC, dorsolateral prefrontal cortex; OC, occipital cortex; SN, substantia nigra; Hipp, hippocampus; Cb, cerebellum. Values are mean concentration ± SEM. Significant differences are indicated by asterisks (student's t test; two-tailed). ***, P = 0.0002; **, P = 0.02; *, P = 0.04.